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Ovariectomized nulliparous rats were treated with estradiol or conjugated equine estrogens (CEEs) either systemically, vaginal CEE, or vaginal placebo cream for 4 wk. Low-dose local CEE treatment resulted in increased vaginal epithelial thickness and significant vaginal growth without uterine hyperplasia.

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Which phrase accurately describes the mechanism of action and roles of conjugated equine estrogens (CEEs) in hormone replacement therapy? Click the card to flip 👆 Binds to nuclear receptors in estrogen-sensitive tissues to replenish low hormone levels in menopause Click the card to flip 👆 1 / 47 Flashcards Learn Test Match Q-Chat morninggirl033

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Four conditions were used: systemic estrogen (50 µg/kg × 3 d, then every other day), placebo vaginal cream, preoperative low dose conjugated equine estrogen cream (CEE, 0.625 µg/d), and continuous CEE cream pre- and postoperatively (Supplemental Fig. 1). In each group, uninjured controls were compared with vaginal injury as a function of time.

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They received a topical vaginal application daily of 0.1 or 1% (w/w) PM cream or a conjugated equine estrogen (CEE) cream (a mixture of estrone, equilin, 17β-dihydroequilin, 17α-estradiol and 17α-dihydroequilin at 0.625 mg total estrogen/g cream) for 28 days. Estrogenic efficacy was assessed weekly by vaginal cytology assay and vaginal pH.

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CEE cream should be used cyclically (3 weeks on, 1 week off) at the lowest dose necessary to control symptoms (0.5-2.0 g cream daily), 53 although in clinical practice, it is often used on a maintenance schedule of one to three doses per week. 2,54 CEE cream is the most extensively investigated vaginal product and has a long-term safety.

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Which phrase accurately describes the mechanism of action and roles of conjugated equine estrogens (CEEs) in hormone replacement therapy? A. Binds to nuclear receptors in estrogen-sensitive tissues to replenish low hormone levels in menopause B. Protects against estrogen-stimulated endometrial proliferation

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CEEs cream at 2 g (equivalent to 1.25 mg of CEE) were evaluated in a 24-week study in which women (n = 79) applied the vaginal cream daily for 21 days, and withheld treatment for 7 days. 4 Of the 28 women with biopsies of sufficient tissue at 24 weeks, there were two cases (2/28; 7.1%) of endometrial hyperplasia: one (3.6%) woman had simple.

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While combined CEE and MPA was the reigning champion of hormone replacement, a few innovative thinkers suggested that bioidentical hormones might be safer and more effective than nonhuman or synthetic molecules.. community. 6 Lee devoted his career to educating women and healthcare providers on the benefits of using progesterone cream to.

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Systemic estradiol with 0.3 mg CEE cream (Premarin Vaginal Cream, Wyeth Pharmaceuticals, Philadelphia, PA) was 9.6 pg/mL 29 , comparable to the higher 25-μg doses of vaginal inserts, although estradiol is a minor component of 0.3 mg CEE. With the approval of vaginally administered prasterone for the treatment of moderate to severe.

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